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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potent CYP3A4 inducers can reduce panobinostat amounts by ~70% and result in cure failure.pentobarbital will lessen the level or impact of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch